Tertiary Lymphoid Organs in Takayasu Arteritis

Tertiary Lymphoid Organs in Takayasu Arteritis

OBJECTIVE The role of B cells in the pathogenesis of Takayasu arteritis (TA) is controversial. We aimed to study the presence of tertiary lymphoid organs (TLOs) in the aortic wall of TA patients. METHODS Hematoxylin and eosin-stained sections from aorta specimens from patients with TA were screened for TLOs. The presence of B cell aggregates (CD20), follicular dendritic cells (FDCs, CD21), an...

Lymphoid Neogenesis and Tertiary Lymphoid Organs in Transplanted Organs

The progressive organization of immune effectors into functional ectopic lymphoid structures, named tertiary lymphoid organs (TLO), has been observed in many conditions in which target antigens fail to be eliminated by the immune system. Not surprisingly, TLO have been recurrently identified in chronically rejected allografts. Although significant progress has been made over the last decades in...

Takayasu arteritis in a young female

Background: Takayasu arteritis is a granulomatous vasculitis which mainly involves the large arterial vessels. The disease is rare and it is more common in females aged between 15-30 years old. In this paper, we report a case of takayasu arteritis in Babol, north of Iran. Case Presentation: A 22 - year old female was admitted to the Department of Infectious Diseases of Rouhani Teaching Hospital...

Tertiary Lymphoid Organs in Cancer Tissues

Tertiary lymphoid organs (TLOs) are induced postnatally in non-lymphoid tissues such as those affected by chronic infections, autoimmune diseases, and chronic allograft rejection, and also in cancer tissues. TLOs are thought to provide important lymphocytic functional environments for both cellular and humoral immunity, similar to lymph nodes or Peyer's patches. TLOs have a structure similar to...

Procalcitonin in takayasu arteritis.